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Monitor Intently (1)phenobarbital will decrease the level or effect of losartan by influencing hepatic/intestinal enzyme CYP3A4 metabolism.phenobarbital will minimize the level or effect of ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers may well